I have been using Vista as my main home OS for a little more than 3 weeks now. The experience has been quite good compared to the PDC build of last year. The OS is more responsive and a lot more stable. I have had around 4 BSODs in the 3 weeks of usage, but that seems to be only when the machine goes into standy and when woken, sometimes BSODed. Apart from this I have not yet seen any major crashes etc.
There is quite a bit of problem if you plan on playing some graphics intensive games. Since I got the new Dungeon Seige 2, two weeks back, I decided to install it on Vista. It works and the performance itself is OK, but the graphics is pathetic, with places where there seems to be multiple layers appearing black etc. So if you don't plan on running any highly graphics oriented apps, then I suppose it should be OK.